Increase, decrease and difference are not the same
Percentage change compares a new value with an original value: (new minus old) divided by old, times 100. Going from 80 to 100 is a 25% increase, but going from 100 back to 80 is a 20% decrease, because the base changed. This asymmetry surprises many people and is why a 50% loss needs a 100% gain to recover.
Percentage difference is used when neither value is the reference, for example two lab measurements or two shop prices. It divides the absolute difference by the average of the two values, giving the same answer whichever order you enter them. For 80 and 100 the percentage difference is 22.22%.
Quick mental shortcuts
X% of Y equals Y% of X, so 8% of 50 is the same as 50% of 8, which is 4. To find 10%, move the decimal point one place left; 5% is half of that, and 15% is the two added together. These tricks are handy for estimating tips and discounts before checking with the calculator.